LIPA, a Risk Locus for Coronary Artery Disease

The ACRE highlights an important new publication exploring the genetic foundations of coronary artery disease. Recent research featured in the European Heart Journal uncovers the variant-to-function relationship at the LIPA locus—offering deeper insight into how genetic variation contributes to cardiovascular risk.

Led by Hanrui Zhang, PhD, of the Columbia University Irving Medical Center, this study advances our understanding of the biological pathways that influence coronary artery disease. By connecting genetic signals with functional outcomes, the work provides a clearer picture of disease mechanisms and may help inform future precision-medicine approaches.

Why This Research Matters

Coronary artery disease remains one of the leading causes of morbidity and mortality worldwide. Investigations like this are essential for:

• Identifying genetic drivers of disease risk
• Clarifying molecular pathways involved in atherosclerosis
• Supporting the development of targeted therapies and preventive strategies

Dr. Zhang’s research represents a meaningful step forward in cardiovascular genetics, reinforcing the importance of collaborative, translational science in improving patient outcomes.

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